What is the first-line treatment for an uncomplicated skin infection?

The first-line treatment for an uncomplicated skin infection is typically cephalexin. This antibiotic belongs to the cephalosporin class and is effective against common pathogens responsible for skin infections, such as Staphylococcus aureus and Streptococcus pyogenes. Cephalexin is often used specifically for conditions like cellulitis or uncomplicated skin abscesses. Its oral bioavailability and favorable safety profile make it a suitable choice for outpatient treatment of these types of infections.

Other options are not considered first-line treatments for uncomplicated skin infections. Ciprofloxacin is primarily indicated for urinary tract infections and some gastrointestinal infections, while vancomycin is reserved for more severe infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). Metronidazole is effective for anaerobic infections and certain protozoal infections but does not target the common pathogens associated with uncomplicated skin infections. Therefore, cephalexin is the optimal choice due to its effectiveness, safety, and suitability for uncomplicated cases.