What is the first line treatment for Tick-Borne Relapsing Fever?

Doxycycline is the first-line treatment for Tick-Borne Relapsing Fever due to its effectiveness against the responsible pathogens, which are spirochete bacteria of the Borrelia genus. This antibiotic works by inhibiting protein synthesis in the bacteria, thereby stopping their growth and facilitating recovery from the infection.

Doxycycline's broad-spectrum activity, particularly against various gram-negative and some gram-positive bacteria, makes it an ideal choice for such bacterial infections. The rapid absorption and good distribution of doxycycline within tissues enhance its efficacy in treating tick-borne diseases.

Other treatment options like amoxicillin, azithromycin, or gentamicin are not the first-line therapies for this specific condition, as they do not have the same proven effectiveness against the Borrelia species responsible for Tick-Borne Relapsing Fever. Consequently, doxycycline remains the standard recommendation in clinical practice for this type of infection.