What is the first line treatment for Late Latent or Tertiary Syphilis (Non-neuro)?

The first-line treatment for Late Latent or Tertiary Syphilis (Non-neuro) is Penicillin G Benzathine. This treatment is specifically recommended due to its long-acting formulation, allowing for sustained levels of the antibiotic in the body, which is effective in eradicating the Treponema pallidum bacterium that causes syphilis.

Penicillin G Benzathine is administered as an intramuscular injection, and its pharmacokinetics make it particularly suitable for treating syphilis, especially when considering the treatment duration needed for late stages of the disease. In cases of Late Latent or Tertiary Syphilis, a single dose of Penicillin G Benzathine is generally sufficient for treatment, providing both efficacy and convenience.

Other options do not align with the recommended treatment guidelines for this stage of syphilis. Aqueous Crystalline Penicillin G is typically reserved for more severe cases or neurosyphilis, while Metronidazole and Ceftriaxone are not indicated for syphilis at all; Metronidazole is used for anaerobic infections and Giardia, and Ceftriaxone is primarily utilized for other bacterial infections.