What is the standard approach for treating uncomplicated Coccidioidomycosis?

Coccidioidomycosis, commonly known as Valley Fever, is primarily caused by the Coccidioides species of fungi. In most cases, particularly uncomplicated cases where the infection does not lead to severe pulmonary or disseminated disease, the standard management approach is supportive care only. This is because uncomplicated Coccidioidomycosis generally resolves spontaneously without the need for antifungal treatments.

Supportive care may include measures such as hydration, pain management, and monitoring of symptoms, but it typically does not involve any specific antifungal medications unless the patient's condition worsens or the symptoms persist for an extended period.

In more complicated cases or when symptoms do not resolve, antifungal therapy may be considered, but for uncomplicated cases, supportive care is deemed sufficient, which is why this approach is the best response. The use of medications such as amphotericin B or fluconazole is reserved for more severe infections or in immunocompromised patients, while voriconazole is used for specific fungal infections but is not the first-line treatment for uncomplicated Coccidioidomycosis.