When are corticosteroids indicated for Mononucleosis?

Corticosteroids are indicated for the management of mononucleosis primarily in cases of significant airway obstruction. This is due to the condition sometimes leading to severe swelling of the lymphoid tissues, including the tonsils and adenoids, which can compromise the airway. In such scenarios, corticosteroids can help reduce this swelling quickly and prevent respiratory distress.

Other situations, such as mild symptoms or general lymphadenopathy, do not warrant the use of corticosteroids due to the risk of potential side effects and the generally self-limiting nature of mononucleosis. The use of corticosteroids in uncomplicated cases may not provide substantial benefit and could potentially interfere with the body's immune response. Thus, their use is limited specifically to critical situations where there is a threat to the airway.