Which antibiotic is the first line for treating infections caused by Clostridium perfringens?

Penicillin G is the first-line antibiotic for treating infections caused by Clostridium perfringens due to its effectiveness against this specific organism. C. perfringens is a gram-positive, anaerobic bacterium that is known for causing various types of infections, including gas gangrene. Penicillin G targets the peptidoglycan layer of the bacterial cell wall, effectively inhibiting cell wall synthesis, which is crucial for the survival and replication of the bacteria.

This antibiotic has been well-studied and is established as a treatment choice due to its ability to penetrate the tissues where these infections often occur, providing adequate concentrations at the site of infection. Other antibiotics listed may not be as effective against C. perfringens or may not provide the necessary spectrum of activity to combat the specific types of infections this bacterium can cause.