Which medication is the first-line treatment for infectious mononucleosis?

The first-line treatment for infectious mononucleosis typically involves supportive care rather than a specific antiviral medication, as most cases are caused by the Epstein-Barr virus and resolve on their own without targeted treatment. However, if antibiotics are administered, amoxicillin is sometimes mistakenly given due to misdiagnosis, particularly in cases where there may be a concomitant bacterial infection, such as streptococcal pharyngitis.

In general practice, the focus for managing infectious mononucleosis revolves around alleviating symptoms such as fever, sore throat, and fatigue. This can include the use of analgesics, rest, and hydration. Corticosteroids like prednisone may be prescribed in cases of severe symptoms or complications, but they are not considered a first-line treatment option. Ganciclovir is typically used for cytomegalovirus infections and is not relevant for mononucleosis. Intravenous immunoglobulin (IVIG) is also not routinely used for infectious mononucleosis but may have a role in certain severe cases.

Thus, while amoxicillin is not specifically indicated for mononucleosis, it is mentioned in the context of treating potential secondary bacterial infections. In usual practice, no specific medication is administered as