Which medications should be avoided in Dengue Virus infection due to the risk of bleeding?

In the case of dengue virus infection, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided due to their anticoagulant properties, which can increase the risk of bleeding. Dengue often causes thrombocytopenia (low platelet count), and these medications can further impair platelet function and increase the likelihood of hemorrhagic complications, including gastrointestinal bleeding and other serious bleeding manifestations.

Acetaminophen is typically considered safe and is often recommended for the symptomatic relief of pain and fever in dengue, making the choice to avoid aspirin and NSAIDs particularly important. Antihistamines generally do not have an impact on bleeding risk and do not interact negatively with dengue, while antibiotics are not routinely used in dengue management since the disease is viral, not bacterial. Therefore, the recommendation is to avoid aspirin and NSAIDs to mitigate the risks associated with bleeding in patients with dengue.